Absorption,Deposition and Excretion of Sr 89 by the Chick in Relation to Route of Administration. ∗ †

Abstract

Summary

The maximum concentration of Sr⁸⁹ observed in the blood following an oral dose was observed to occur in about 2 hours and decreased to a negligible quantity in 24 hours. The rate of uptake of Sr⁸⁹ by the bone was found to parallel the rate of increase in activity of the blood, but the former continued to increase to 14 hours post-injection time. The eyes took up radiostrontium in a similar way, but in much lower concentrations.

It was observed that the most efficient excretion was accomplished when the isotope was ingested orally, and the lest efficient elimination was observed when the isotope was administered by intraperitoneal injection. All routes of administration, except the oral route, resulted in higher activity in the urine than in the feces with the highest urinary excretion occurring as a result of intramuscular injection.