Rat Epiphyseal Cartilage

Abstract

Conclusions

The effect of papain on REC MPS and S³⁵ MPS incorporation has been studied in vitro. Papain treatment, both in vivo and in vitro, has been demonstrated to have a greater effect on the water-soluble fraction (PP) of the total MPS from this tissue. Small doses of papain, administered in vivo, were associated with an increased S³⁵ MPS incorporation, evident within 6 hours and present up to 24 hours. These studies suggest that extracellular alterations of MPS in their physiologic state (protein complexes) have affected the biologic processes and matrix integrity of REC.