Abstract
Summary
The increased intake of 0.15 M NaCl solution by adrenalectomized rats was reduced progressively by subcutaneous administration of increasing doses of the miner-alocorticoid hormone, desoxycorticosterone acetate (DOCA). When the administered dose exceeded 100 μg/100 g body weight/day, the spontaneous NaCl intake returned toward that of control, adrenalectomized rats. Thus, a U-shaped dose-response relationship was observed between NaCl intake and dose of DOCA administered. Dietary administration of spironolactone, the mineralocorticoid antagonist (400 mg/kg food), simultaneously with graded doses of DOCA, inhibited the effect of DOCA on spontaneous NaCl intake of adrenalectomized rats. The results of this experiment provide further indirect evidence for the specificity of control of spontaneous NaCl intake by blood level of mineralocorticoid hormone.
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