Induction of Mitochondrial a-Glycerophosphate Dehydrogenase by Thyroid Hormone

Abstract

Summary

Starvation was found to decrease both the endogenous LM-GPDH level and the induction of LM-GPDH by T₃-treat-ment. Different diets of protein, carbohydrate, or fat along with a salt-mixture were used to refeed 4-day fasted rats; it was found that protein, required for restoration of endogenous enzyme levels, did poorly restore T₃-induction; however, either fat or carbohydrate, which poorly restored endogenous enzyme level, did restore T₃-induction. These observations suggest that T₃-induced LM-GPDH synthesis is independent of the dietary protein and that the diminution of T₃-induction after fasting may primarily result from energy deficiency.