Abstract
Summary
Mice which were subjected to repeated treatments of endotoxin plus 150 R X-rays developed leukemia to the same extent as the drug-free irradiated controls. Treatments of mice with AET prior to each exposure to 150 R X-rays reduced the incidence of leukemia in them. Mice which had been inoculated with endotoxin were thereby immunized against the radioprotective and leukemia-sparing benefits of the drug. When AET replaced endotoxin in the above scheme, the radioprotective and leukemia-sparing benefits of AET were sustained.
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