Effect of Reciprocal Allogeneic Renal Transplantation Between Dalmatian and Non-Dalmatian Dogs on Urinary Excretion of Uric Acid. ∗

Abstract

Summary and Conclusions

When a kidney from a non-Dalmatian dog was substituted for the kidneys of a Dalmatian and vice versa, with rejection delayed by immunosup-pressive therapy, the Dalmatian recipient continued to excrete the large amounts of uric acid in the urine that are characteristic of the species whereas the non-Dalmatian continued to excrete small amounts of uric acid, characteristic of non-Dalmatians. These data cast doubt on the concept currently held that the kidneys are predominantly responsible for the differences in urinary excretion of uric acid, characteristic of Dalmatian and non-Dalmatian dogs.