Abstract
Summary
Intravenously administered cholesterol-fed chick serum elevated liver cholesterol levels and depressed hepatic cholesterol synthesis in recipient mice. Serum from lithocholic acid-fed chicks, although supplying a greater quantity of cholesterol than that from cholesterol-fed chicks, did not alter cholesterol levels or cholesterol synthesis in liver of recipient mice. The percentage hepatic uptake of cholesterol from serum by liver of recipient mice was significantly enhanced by administration of cholesterol-fed chick serum and was depressed in mice treated with lithocholic acid-fed chick serum. These data are interpreted to indicate that cholesterol in the serum of chicks ingesting lithocholic acid is bound in a lipoprotein complex which does not readily enter the liver cell.
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