Abstract
Summary
The concentrations of ATP in rat liver were determined at 2, 8, and 24 hours after stomach-tube feeding of ethanol. ATP concentration nearly doubled 8 hours after feeding but returned to control levels by 24 hours. This acute effect of ethanol ingestion was not sex dependent. When male rats were fed ethanol for 2 months or longer, the liver ATP content decreased. This depression in ATP persisted for as long as 16 months but returned to control levels 2 days after ethanol was withdrawn. These results of chronic ethanol feeding were found only in the experiments with male rats, not females. The results with males were duplicated by chronic acetaldehyde feeding.
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