Biotin Deficiency in Mice and Depigmentation

Abstract

Summary

Uncomplicated and reversible biotin-deficiency symptoms such as retarded growth, poor appearance, changes in skin, and impaired hair development and depigmentation were developed in young black mice by the inclusion of antibacterial agents in purified rations but without the use of dried egg white. The severity of the deficiency and the prevalence of depigmentation of the hair appeared to vary with the carbohydrate portion of the diet. The most severe deficiencies were obtained when a combination of glucose, sucrose, starch, and cellulose were fed in the diet.