Depression of Liver Affinity for Iron with Iron Overload. ∗

Abstract

Summary

When liver slices were incubated in Ringer's solution containing Fe⁵⁹ the uptake of the radioactive iron was significantly decreased if the rats were previously overloaded with iron parenterally. Oral administration of iron did not produce the same degree of overload, and subsequently there was no significant decrease in the affinity of the liver for Fe⁵⁹ in vitro. The deposition of histochemically demonstrable iron in the liver was associated with the presence of a DPAS positive material and acid phosphatase.