Abstract
Summary
The possibility that erythropoietic stimulating factor (ESF) might be involved in the relationship between tumor and virus was tested in vitro. Four experimental situations were studied: (A) Adenovirus, type 12 inoculated into hamster cell culture, (B) Adenovirus, type 4 into hamster cell culture, (C) Adenovirus, type 12 into monkey cell culture and (D) Adenovirus, type 4 into monkey cell culture. Each of these cultures was extracted and assayed for ESF. In addition, other cultures containing only virus or cells in medium or medium alone were extracted and assayed.
Extracts of cultures of hamster cells inoculated with human adenovirus, type 12, were found to contain an ESF. This material was found only in small amounts in the other experimental situations. The occurrence of this ESF primarily in the experimental situation in vitro analogous to that in vivo which results in tumor formation suggests that an ESF-like material may be associated with the process of cell division in both situations.
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