Effects of a Synthetic Vasopressin on Na +,K +,and H + Exchanges in the Rat. ∗

Abstract

Summary

PLV-2, a synthetic vasopressin, administered subcutaneously in the nephrectomized rat, produces a shift of water and, in greater degree, of Na out of the extracellular space and into cells as measured chemically in aorta and skeletal muscle. No shift of K can be measured. When arterial blood in the intact rat is monitored with glass electrodes following intravenous injection of PLV-2, the shift of Na in excess of water into cells is reflected by a rise in blood K⁺. Since these changes are associated with an increase in blood H⁺ it is suggested that ion exchange processes may be involved.