Abstract
In former experiments 1 it was shown that after the intravenous injection of large amounts of dextrose (4 g. per kilo) into dogs the sugar rapidly disappears from the blood stream so that after 11/2 hours after the end of the injection the blood-sugar falls nearly to its original figure. In the present experiments the same procedure was carried out on completely depancreatized dogs. In these cases the blood-sugar did not fall to its original value or near it; at the end of 11/2 hours it was on the average more than twice as high. The following is a comparison of the average figures:
A similar difference was observed also in nephrectomized dogs.
It is claimed by some investigators that the glycemia following depancreatization is due to an over-production of sugar. It is evident that the hyperglycemia in our cases of depancreatization can not be due to such a factor. We shall not discuss here whether our results can be adequately explained by the assumption that the removal of the pancreas causes a decrease of consumption of dextrose by the body tissues. We wish, however, to indicate that some of our facts hint at the possibility of a change in the permeability of the endothelia of the circulatory apparatus as a factor in the results of depancreatization.
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