Abstract
Summary
Growth of Mycobacterium acapulcensis is inhibited by D-cycloserine. This effect is completely reversed by equimolecular concentrations of D-alanine. L-alanine is totally inactive while DL-alanine is only effective at higher concentrations. L-alanine antagonized the protection afforded by D-alanine, a fact that cannot be explained by a simple competition between these diastereoisomers at the cell membrane level. In the presence of D-cycloserine a mucopeptide accumulates in the sensitive strain and also in the resistant mutant when allowed to grow at high antibiotic concentrations.
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