Abstract
Summary
The plasma fluoride concentration in rats was not altered by widely varying fluoride intakes which were sufficiently different to produce a 3-fold variation in skeletal fluoride load. Parathyroid extract administered to animals resulted in a significant increase in plasma calcium without altering plasma fluoride concentration. Food deprivation of rats for a period of 7 days, with access to distilled water, saline solution and sugar did not significantly alter the mean serum fluoride level of the experimental animals. The results indicate that the fluoride content of body fluids is adjusted during periods of high fluoride intake or long periods of food deprivation by the skeleton. Additiona studies are required to delineate the role of the kidney in fluoride homeostasis in conditions of parathyroid extract mobilization of the skeleton and inthose of deprivation of fluoride intake.
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