Abstract
Summary
Polydiethylstilbestrol phosphate (PSP), a water soluble polyester of phosphoric acid and diethylstilbestrol, was injected in rats and a cow and the distribution and excretion of radioactivity were followed in both species. After a subcutaneous or intramuscular injection the bulk of the radioactivity was accumulated at the site of injection. The disappearance of radioactivity from this depot was very slow. As late as 90 days after the injection into rats, 20% of the administered radioactivity was still accumulated at the site of injection. The liver was very effective in removing labeled material from circulating blood. Twenty-four hours after intravenous injection in rats, about 50% of the radioactivity was recovered from this organ. The distribution of radioactivity in the cow indicated that the polymer was preferably accumulated in organs containing reticuloendothelial cells.
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