Abstract
Summary
The minimum protective dose of ethynyl estradiol (EE) which prevented pregnancy in all female rats treated before mating (MPDioo) was found to be 0.05 mg/kg body weight. This concentration of EE appeared to increase the sexual receptivity of some of the females. In attempting to clarify the mode of contraceptive action at the MPD100, EE was found to inhibit pituitary gonadotropin release but not ova transport or ova nidation. This was concluded from the facts that EE inhibited compensatory ovarian hypertrophy of the unilateral ovariectomized rat but did not prevent implantation when given after coitus, although a high rate of resorption was noted. In addition/ the MPD100 of EE did not inhibit formation of deciduomata.
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