Abstract
Summary
The influence of a number of nicotinic acid analogs and homologs (nico-tinic acid, nicotinamide, picolinic acid, pyri-dine 3-sulfonic acid and ω(3-pyridyl) acetic, propionic and butyric acids) and sex hormones (testosterone, androsterone, epiandro-sterone, estradiol, estriol, estrone, and hexes terol) upon the ascorbic acid catalyzed oxidation of methyl linoleate has been studied. Experiments were carried out in phosphate (pH 6.8) and Tris (pH 8.5) buffers. The extent of oxidation was measured by the thio-barbituric acid color reaction. None of the sex hormones had any effect on the oxidation of methyl linoleate in either buffer. In phosphate buffer only ω(3-pyridyl) propionic and butyric acids failed to enhance oxidation of methyl linoleate after 6 hours. In incubations carried out in Tris buffer picolinic acid inhibited oxidation of methyl linoleate. None of the other test compounds had any effect. In the absence of test compounds the type of buffer did not affect the rate of methyl linoleate oxidation.
We are indebted to Lepetit, S. A., Milan, Italy for generous gifts of the nicotinic acid, nicotinamide, and ω(3-pyridyl) acetic, propionic and butyric acids used in these experiments.
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