Abstract
Summary
Rats with chronic implanted platinum black electrodes were used to evaluate the effect of various solutions on brain resistance. Intragastric or intraperitoneal loads of water, hypertonic glucose, sucrose, and NaCl, alone or in various combinations were tested. Intraperitoneal sucrose and intragastric NaCl decreased AC resistance, as would be expected from their known osmotic effects in causing shifts of water from the extracellular compartment. Hypertonic glucose loads did not decrease resistance but were equivalent to water loads in their effects because of rapid absorption and cellular utilization. These results are in agreement with previous behavioral studies in showing that ingested hypertonic glucose does not dehydrate the animal and that current notions about the importance of the colligative properties of ingested glucose in controlling food intake are inadequate.
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