Abstract
Summary
Studies with the electric transparent knife fish, E. virescens, have been extended to include observations on methylphenidate, pentylenetetrazole, phenobarbital, morphine, and nalorphine. Characteristic qualitative and quantitative responses were obtained with methylphenidate, phenobarbital, and morphine. Pentylenetetrazole produced no consistent effects. Nalorphine reversed the depressant effects of a preceding dose of morphine. The data suggested that the fish developed tolerance to morphine as well as physical dependence on this drug. The system studied appeared to be suitable as a bioassay technique. The observed drug effects were obtained with concentrations approximately the same as those which have effects in man.
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