Abstract
Summary
Tissue cholesterol concentrations, sterol-C14 elimination rates, and fecal steroid-C14 time-patterns were determined in intact and hypophysectomized rats. Tissue cholesterol was slightly elevated in the hypophysectomized animals. The rate of tissue sterol-C14 elimination was greatly reduced in hypophysectomized rats. Hypophysectomized rats excreted fecal steroid-C14 at one-half the rate of normal animals, with the greater reduction in the bile-acid-C14 fraction. The incorporation of mevalonic acid-2-C14 into tissue cholesterol at the end of one hour was about the same in both groups.
Get full access to this article
View all access options for this article.