Abstract
Summary
Measurements were made of the size of the exchangeable albumin pool and the plasma flow rate in the papilla of dogs during hypertonic mannitol diuresis. The former, in ml plasma/100 g tissue, was determined by comparison of labeled albumin in the papilla with that in peripheral plasma. The latter was computed by determining the I131 albumin accumulation rate in ml plasma/0.25 min/100 g tissue. The results were compared with similar studies made in hydropenic dogs.
The data are interpreted to support the concept of an extravascular location of albumin in the renal papilla. In addition, it appears that the reported washout of the osmolality gradient and the increased average velocity of plasma flow in this region are probably due to increased reabsorption of fluid into the vasa recta rather than to an increase in inflow of blood to the medulla.
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