Abstract
Summary
In experimental anti-edema studies, rats were subjected to varying numbers of hind limb volume measurements during a 6-hour period. Edema was induced by sub-plantar injection of mustard. Intact rats having 2 to 5 post-mustard determinations while under light ether anesthesia, had less edema at 6 hours than those having only a single 6-hour measurement. This difference was not observed in similarly anesthetized bilaterally adrenalectomized or bilaterally adreno-demedullated rats, or in unanesthetized intact rats. These results suggest that the adrenal medulla is implicated in the control of experimental inflammatory edema.
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