Abstract
Summary
The quantitative distribution and excretion of aminonucleoside-8-C14 was studied in normal and nephrotic rats. In the 8 hours following subcutaneous administration the normal rat excreted 65–70% of the dose in the urine, half of which was unchanged PA, and 15–26% in the feces. Despite being the target organ, the kidney contained less than 0.25% of the dose, while the liver contained considerably more. Nephrotic rats excreted much less of the radioactivity-total as well as in the form of unchanged PA. The decrease in excretion of total radioactivity was attributed to its retention in an expanded pool of body water characteristically seen in the nephrotic syndrome.
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