Abstract
Summary
A study of the effects of cold-acclimation and de-acclimation on the immune response in 8-week-old mice was conducted. The mice were exposed to an ambient temperature of 4°C for 4 weeks and some of these were then de-acclimated at room temperature (23°C) for an additional 4 weeks. In each case, controls were maintained at 23°C. The antigen used was coliphage T2r+ and the levels of circulating antibody were determined in terms of the remaining serum plaque-forming units of coliphage. Neither acclimation nor de-acclimation, under these conditions, resulted in significant change in the levels of circulating coliphage antibodies.
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