Abstract
Summary
Hepatic blood flow was measured in adult mongrel dogs by the brom-sulphalein method before, during and following constant infusion of 500 mg/kg ethyl alcohol. The blood alcohol concentration increased linearly to a maximum of 84.6 mg % and decreased linearly during the post-infusion period. An insignificant decrease in alcohol metabolism was observed with elevated blood ethanol levels. Extraction of BSP was decreased by alcohol administration. The respiratory quotient increased in response to elevated carbon dioxide production. Total body heat production increased during the infusion period. Ethyl alcohol did not alter hepatic blood flow significantly, but metabolic studies indicated hepatic oxidative depression.
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