Abstract
Summary
Splenectomized animals given intraperitoneal injections of methylcellulose developed a much higher incidence of hypertension than did similarly treated intact rats, although degree of hypertension in both groups was of much the same order of magnitude. The adrenals, liver and kidneys were enlarged to a comparable degree in either group as compared with those of untreated controls. Splenectomized methylcellulose-treated rats, however, developed significant cardiac hypertrophy whereas this was not true of similarly treated intact rats. The results are interpreted as reflecting the more severe damage inflicted by methylcellulose upon animals deprived of one of the organs most concerned with removal of this material from the circulation.
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