Abstract
Summary
Erythrocyte and plasma transfer times determined simultaneously with Cr51 tagged cells and radio-iodinated human serum albumin (RISA) in normal parabionts at less than 30 days after union were statistically similar to each other, but plasma half-time transfer was as long or longer than that for erythrocytes in all but one of 33 pairs. Normal pairs reinvestigated 10 and 15 months after surgical union showed some slowing of cross circulation. Pairs in a state of intoxication, as determined by clinical appearance corroborated by differentials in peripheral blood values, showed a great slowing of cross-circulation time. In addition to this slowing of cross-circulation time the intoxicated pairs exhibited plasma transfer faster than that for erythrocytes which was opposite to the pattern for normal parabionts. When injected into the anemic animal, the majority of tagged erythrocytes crossed to the hyperemic rat demonstrating unequal exchange; when injected into the hyperemic animal, the erythrocytes tended to remain in that animal although some mixing did occur.
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