Abstract
Summary
The path of cobalt-60, administered alone as cobaltous chloride or with any one of the chelating agents 1-nitroso 2-naphthol, SDDC, rubeanic acid, BAL, EDTA or cysteine, is traced by studying the tissue distribution at various times after intravenous administration to albino rats. With ionic cobalt and with a number of chelates, an initial accumulation of radioactivity in the liver is noted, even though subsequent distribution varies widely. The 1-nitroso 2-naphthol chelate follows the route Blood → Liver → Skin, Bones and Muscles → Excretion. EDTA- and cysteine-chelates exhibit a marked apathy for the liver, but preferentially concentrate in the skin and bones. Quantitatively, the liver, skin, bones and muscles are the chief tissues of physiological importance in cobalt metabolism.
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