Abstract
Summary
On the basis of these experiments, we conclude: 1, that the EST is a highly reproducible bioassay for endotoxin; 2, that the EST is about 10 times less sensitive than the chick embryo in terms of volume for volume of test material available. But when the concentration of endotoxin per unit volume is very low, the EST can be much more reliable than the chick embryo test for detecting the presence of endotoxin; 3, that serotonin does not give false positive ESTs for endotoxin; and 4, that circulating endotoxin may be detected in rabbits up to 51/2 hours after a lethal dose of endotoxin intravenously.
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