Abstract
Summary
Coxsackie A-21 virus (strain 48560) lost the capacity to agglutinate human erythrocytes after passage in KB or HeLa cell cultures. Hemagglutinin could be retained by passage at high dilution in such cells. By adsorption onto erythrocytes it was possible to separate distinct hemagglutinating (HA+) and non-hemagglutinating (HA-) particles. It was found that malignant cells favored multiplication of the HA- particles, whereas primary human embryonic epithelial cells and semi-continuous diploid human embryonic fibroblastic cells favored growth of the HA+ particles.
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