Abstract
Summary
The absorption, distribution, excretion, and serum binding of tetracycline and methacycline, a new analogue, have been compared. The higher and more sustained levels of the latter drug noted after oral and intravenous administration in man appear to be due to delayed renal excretion and more limited distribution rather than to enhanced gastrointestinal absorption. These differences are thought to be a reflection of greater serum binding of methacycline.
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