Abstract
Summary
Peritoneal exudates were induced in female rabbits and collected either 1, 5 or 30 days after total body exposure to 400 r and 1 or 5 days after 500 r. Exudate cells from unirradiated rabbits served as controls. Phagocytin was extracted from the exudate cells (heterophils) and tested for bactericidal activity against Escherichia colt, Salmonella enteritidis, Klebsiella pneumoniae and Pseudomonas aeruginosa. Phagocytin from cells collected 1 day after exposure to 400 or 500 r and 5 days after exposure to 500 r showed a decreased activity against all the test micro-organisms. Phagocytin from cells collected 5 days after exposure to 400 r showed only a slight change in activity from controls. A marked increase in phagocytin activity was observed in extracts of cells collected 30 days after exposure to 400 r.
The authors are indebted to Dr. W. S. Moos, Dr. J. W. Yusken and Mr. R. Haas, Radiology Dept., College of Medicine, Univ. of Illinois, for the dosimetry and to Miss Mabel Counelis for irradiating the rabbits.
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