Abstract
Summary
Renal hypertensive rats on an all-meat diet developed hypercholesterolemia and coronary atherosclerosis within 16 weeks. Intact meat-fed, intact chow-fed, and renal hypertensive chow-fed rats developed neither condition by 50, 20 and 20 weeks respectively. Aortas of all animals chow- or meatfed were normal. Thus, it appears that hypertension coupled with a high fat, high protein, but low cholesterol, diet is related to the production of hypercholesterolemia and coronary atherosclerosis. It is suggested that such a system may serve as an in vivo tool for the study of prevention, development and possible reversal of coronary atherosclerosis.
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