Further observations on the toxicity of tin

Abstract

In a preliminary communication 1 from this laboratory, the results of experiments with the double salt of tin tartrate were announced. Experiments performed since with tin tartrate have shown that like the double salts, it caused marked injury to the kidneys. Large amounts of albumin were present in the urine of rabbits when administered subcutaneously and intravenously but larger doses of the normal salt were required to produce this effect.

The amount of tin as the double salt necessary to produce a very marked albuminuria was 20 to 30 per cent less than in the form of tin tartrate. Observations on the action of stannous and stannic salts failed to show any noteworthy difference. The effect of concentration indicated marked differences both when injected intravenously or subcutaneously. Thus 20 milligrams of tin per kilo, injected intravenously, produced a moderate albuminuria when the amount of tin per c.c. was 1.5 milligrams; much greater amounts of albumin and large amounts of sugar when each c.c. contain 8 milligrams of tin; acute death when each c.c. contained 20 milligrams of tin.