Abstract
Summary
Decanoic hydroxamic acid (DHA) was markedly inhibitory to growth of certain fungi, both mycelial and yeast-like. Quantitatively it was approximately 4 times as active as the unsubstituted acid on Candida albicans. Activity was apparently not mediated through a release of free hydroxyl-amine. Toxicity upon parenteral administration to experimental animals was not primarily to liver, spleen, bone marrow, or kidney. Topical application of 1% DHA in propylene glycol on patients with cutaneous C. albicans infections caused considerable regression of lesions in one week. No evidence of sensitization or primary irritation was observed in this group.
Get full access to this article
View all access options for this article.