Abstract
Summary
Angiotensin II (valine-5 angiotensin II amide) and pitressin were administered intravenously during mannitol and water diuresis to subjects with diabetes insipidus. Angiotensin II in doses of 0.0025 to 0.0050 μg per kg per minute caused a small but definite increase in blood pressure in 5 of 7 experiments, a decrease in endogenous creatinine clearance of about 11%, and a decrease in urine flow and water clearance of about 40%. The rate of sodium excretion was depressed by nearly 50%, while that of potassium decreased much less. Pitressin produced changes of water excretion qualitatively similar to those caused by angiotensin II. However, this effect was achieved without alteration in blood pressure, although filtration rate decreased. Further, pitressin did not consistently affect excretion of sodium and potassium. The results suggest that angiotensin II at the dose-ranges examined inhibits water and salt excretion by direct tubular action.
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