Effect of Vitamin B 6 And Magnesium on Renal Deposition of Calcium Oxalate Induced by Ethylene Glycol Administration. ∗

Abstract

Summary

Oral administration of ethylene glycol to rats and the resultant renal de-position of calcium oxalate were studied in terms of dietary levels of Vit. B₆ and magnesium. Under the conditions of these experiments partial protection against oxalate deposition was achieved with excessive dietary Vit. B₆ while complete protection resulted when large amounts of MgO were fed. The in vivo oxidation of ethylene glycol to CO₂ was found to be related to amount of Vit. B₆ administered. Dietary magnesium levels, however, did not affect oxidation of ethylene glycol and it is suggested that dietary magnesium protects against renal deposition of calcium oxalate by altering the solvent characteristics of urine.