Abstract
Summary
Paper electrophoresis and ultracentrifugation have been employed to demonstrate the completeness of β-lipoprotein isolation from chick plasma by a polyanion precipitation technique employing Mepesulfate as the precipitating agent. Data are presented demonstrating that in the chick made hypercholesterolemic by cholesterol feeding, the increase in plasma cholesterol occurs almost entirely in the β-lipoprotein fraction. Lipid distribution in the α-lipoprotein fraction of plasma has been determined for chick, rabbit, guinea pig, rat, mouse and dog as well as for the human. The chick, rat, mouse and dog were found to have more than 50% of the total plasma cholesterol bound to the α-lipoproteins in contrast to man, the rabbit and guinea pig. Values are also presented for distribution of lipid phosphorus and glycerides.
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