Abstract
Summary
The effects of sodium salicylate on prophylactic counter-irritation, accomplished by irritating the opposite ankle 15 hours prior to the test ankle, were studied in rats. It was found that: (1) The capacities to inhibit edema by prophylactic counter-irritation and sodium salicylate were similar; (2) Sodium salicylate administered 1 hour prior to irritation of the test ankle did not increase the degree of inhibition produced by prophylactic counter-irritation; and (3) Sodium salicylate given 1 hour prior to the prophylactic counter-irritation caused the latter's anti-edema effect to be lost.
Get full access to this article
View all access options for this article.