Clinical and Serologic Responses in Volunteers Given Vacuolating Virus (SV 40 ) by Respiratory Route

Abstract

Summary

SV₄₀ virus present as a contaminant in a pool of respiratory syncitial virus prepared in cultures of rhesus monkey kidney cells was inoculated by the respiratory route into 35 adult volunteers: 8 of these received SV₄₀ virus preparation in which the RS virus component was neutralized by addition of RS antiserum. None of the test subjects developed signs or symptoms attributable to inhalation of SV₄₀. SV₄₀ virus was recovered from throat swab specimens of 3 of the volunteers 7 or 11 days after exposure. SV₄₀ neutralizing antibody in titers ranging from 1:5 to 1:80 appeared in the blood of 22 of the 35 test subjects.