Abstract
Summary and Conclusions
Shock induced in rats by temporary occlusion of the superior mesenteric artery after pretreatment with various antibiotics and induction of resistance by drum training and by repeated administration of bacterial endotoxin was studied. Terramycin, Neomycin or Gantrisin given orally for 6 days clearly protected rats, whereas those treated with Aureomycin or Chloromycetin were not protected. Adaptation to drum trauma did not circumvent the lethal effects of bowel occlusion. Tolerance to bacterial endotoxins was only moderately effective against occlusion shock.
It was concluded that the protective action afforded by certain antibiotics was probably due to their local action in preventing pathological changes in the intestinal tract and not to prevention of a systemic bacteremia.
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