Abstract
Summary
Complement-fixation has proved to be a rapid, sensitive method of testing DNA preparations obtained from Brucella abortus for DNAase-sensitive antigens, and similarly, for analyzing antisera for possible antibodies against DNAase-sensitive antigens. Considerable variation in such antigens has been found among various DNA-rich preparations isolated from the same Brucella abortus strain and among antisera prepared against such preparations. The percentage of rabbits that yielded antibodies against DNAase-sensitive antigens following immunization with a preparation selected for DNAase-sensitive antigens was greater than that obtained in prior studies with unselected immunizing preparations.
The efficient technical assistance of Miss Christine Pootjes, Mrs. Janet Collins, and Mrs. Janet Feder is gratefully acknowledged.
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