Abstract
Summary
Angiotensin II was administered at rates of 0.3 to 0.6 μg per minute over 6 to 24 hours to 6 subjects with hypertension of various etiologies under conditions of positive and negative sodium balance. Angiotensin produced hypernatriuresis under condition of positive sodium balance. The effect was most marked in those subjects having a diastolic blood pressure above 110 mm Hg.
Miss S. Goodman, Mrs. S. Beacher and Miss M. E. Novotny provided technical assistance. Angiotensin II (Hypertensin Ciba) and aldosterone (d-aldosterone Ciba) were obtained through the courtesy of Dr. W. E. Wagner, Summit, N. J.
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