Abstract
Summary
Mammogenic potencies of a number of crude and purified anterior pituitary fractions were determined by estimation of mammary gland desoxyribosenucleic acid (DNA) in treated ovariectomized mice. Crude bovine AP, initial residue (IR) obtained by depleting AP of known hormones, a newly developed mammogen extracted from IR (mammogen “C”) and lactogenic preparation produced lobule-alveolar development. Extracted mammogen “C” was white, crystalline, apparently salt-free and water soluble. Crude and purified FSH and growth hormone exhibited little or no mammogenic effects when injected with a synergizing dose of estradiol benzoate in ovariectomized mouse.
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