Abstract
Summary
1. Administration of small oral doses of papain to human patients results in production of a plasma antithrombin agent demonstrated by prolonged thrombin clotting time in vitro. 2. Administration of large oral doses of papain to human patients results in a decrease in thrombin clotting time, and an acceleration of euglobulin clot lysis time. 3. These experiments demonstrate that orally administered papain produces a systemic effect, although in all probability it is not itself absorbed.
We are indebted to Mr. N. Stasilli of the Warner-Lambert Research Inst, for statistical computations.
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