Differences in Thyroid Function of Several Strains of Mice. ∗ †

Abstract

Summary

I¹³¹ uptake and retention by the thyroid of several strains of mice was measured with an in vivo technic and compared with the histological reaction of the thyroid to sulfadiazine administration. The order in which the strains of mice rank in their thyroid hormone output rate was found not to parallel the order in which the strains rank in their histological reaction to sulfadiazine. Degree of reaction to sulfadiazine is thus not directly dependent upon the normal rate of thyroid hormone output, but they represent 2 separate independent aspects of the pituitary-thyroid axis.