Abstract
Summary
Guinea pigs were sensitized by intravenous injection of known amounts of antibody or antigen and challenged after varying latency periods with the other reactant. A comparison of the results obtained by local accumulation of dye after intradermal challenge (Ovary test) and by the classical Schultz-Dale test showed that the former behaves as a more sensitive test, particularly when small amounts of antibodies or antigen are involved and after inadequate latency periods. It is therefore justifiable to use Ovary's test as a reliable substitute for the Schultz-Dale technic in qualitative and quantitative assays of anaphylactic sensitization.
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