Abstract
Summary
Plasma disappearance of parenterally injected radio cyanocobalamin in various animals was determined. Beginning 48 hours after injection 2 disappearance curves were found in female rabbits and chickens of both sexes, but only 1 disappearance curve was present in male rabbits and male human subjects. The most rapidly disappearing component (Component A) was similar in rabbits and chickens (T 1/2 = 4.2 days) and human subjects (T 1/2 = 5.7 days). The more slowly disappearing component (Component B) in female rabbits and chickens of both sexes approximated a biological half life of 29.9 days. In dogs of both sexes, plasma disappearance rate was very rapid (T 1/2 = 1.5 days). Tissue radioactivity varied between tissues of the same species and between the various species studied.
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