Abstract
Summary
Two relatively small doses of cortisone acetate administered to pregnant mice caused 1.4 and 12.0% cleft palate, respectively, in the offspring. A hypocaloric diet, consisting of about 40% of ad lid. daily intake, given during middle 3rd of pregnancy, produced 5.6% cleft palate. The doses of cortisone plus the restricted diet caused 36.8 and 50.7% cleft palate, respectively. These results are discussed.
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